Endocrine Abstracts

Introduction/case report: Diabetes mellitus is an important clinical manifestation of catecholamine excess in patients with pheochromocytoma, and glucose control is usually better after tumour removal. Both impaired insulin secretion and increased insulin resistance have been implicated as underlying causes. We describe the case of a 38-year-old male patient diagnosed with left adrenal pheochromocytoma and personal history of diabetes mellitus diagnosed at age 36, under treatm...

Background: Prolactinomas (PRL) are pituitary adenomas mainly characterized by hyperprolactinemia. In addition to the endocrine effects of prolactin, metabolic alterations have been described in PRL patients. Changes in inflammatory parameters have recently been identified in pituitary adenoma patients. Since both, metabolic (MM) and inflammatory markers (IM) showed promising results in characterization/prognosis of tumor patients, it is tempting to speculate whether those mig...

Introduction: The differential diagnosis between arginine vasopressin deficiency (AVP-D), formally known as central diabetes insipidus, and primary polydipsia (PP) is challenging. In clinical routine, psychopathologic findings are often used as a hallmark for diagnosing PP; thus, it is often referred to as psychogenic polydipsia. Yet, psychopathologic characteristics are barely assessed in patients with AVP-D, and to date, no data exist comparing AVP-D and PP with regard to th...

The differential diagnosis between arginine vasopressin deficiency (AVP-D), known as central diabetes insipidus, and primary polydipsia (PP) is challenging. Psychopathologic findings are often used as a hallmark for diagnosing PP; thus. Yet, psychopathologic characteristics are barely assessed in patients with AVP-D, and to date, no data exist comparing AVP-D and PP with regard to these features. Therefore, in this study, we aimed to compare levels of anxiety, depression, alex...

Background: The main challenge in the diagnosis of arginine vasopressin deficiency (AVP-deficiency, formerly known as central diabetes insipidus), is its distinction against primary polydipsia. Hypertonic saline stimulated copeptin showed a high diagnostic accuracy of 97% in distinguishing between AVP-deficiency and primary polydipsia (Fenske W, Refardt J, NEJM 2018), but comprises discomfort for patients and requires close sodium monitoring. Arginine stimulated copeptin showe...